|(2S,3R,4S,5S,6R)-2-(((1aS,1bS,2S,5aR,6S,6aS)-6-羟基-1a-(羟甲基)-1a,1b,2,5a,6,6a-六氢环氧乙烷并[2',3':4,5]环戊二烯并[1,2-c]吡喃-2-基)氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇|CsnPharm

CAS No.: 2415-24-9

梓醇 Catalog No. CSN10557

Synonyms: 梓醇;Catalpinoside

Catalpol is a naturally occuring iridoid glucoside which exhibits anti-inflammatory activity and stimulates the production of adrenal cortical hormones.

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技术信息

生物活性

描述Catalpol is an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects. Catalpol (25-100mg/kg; intraperitoneal injection; once) treatment clearly reduces blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal ischemia/reperfusion-injury (IRI) mice. Catalpol markedly reduces the expression of PI3K, Akt and eNOS levels, and suppresses the TNF-α, IL-1β, IL-6 and IL-10 activities^[3]. In vivo, catalpol treatment significantly improved adriamycin-induced kidney pathological changes and decreased the number of apoptotic cells. In vitro, catalpol markedly decreased the intracellular accumulation of adriamycin and reduced the calcium ion level in podocytes and then attenuated apoptosis^[4]. Catalpol exerts an anti-diabetic effect in different animal models with an oral dosage ranging from 2.5 to 200 mg/kg in rats and 10 to 200 mg/kg in mice^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7599 mL
- 13.7996 mL
- 27.5992 mL
- 5 mM
- 0.5520 mL
- 2.7599 mL
- 5.5198 mL
- 10 mM
- 0.2760 mL
- 1.3800 mL
- 2.7599 mL

技术信息

CAS号

2415-24-9

储存条件

粉末: Inert atmosphere,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H22O10

运输

蓝冰

分子量

362.33

别名

梓醇;Catalpinoside

溶解度

DMSO	200.0 mg/mL (552.0 mM)
Water	120.0 mg/mL (331.2 mM)

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